Understanding Wilms Tumor: What Causes It?

Understanding Wilms Tumor: What Causes It? | Dr. Vishesh Dikshit

Wilms tumor, also known as nephroblastoma, is a rare type of kidney cancer that primarily affects children. While this condition is relatively uncommon, it’s crucial to understand what causes it and how it can be treated. In this blog, we’ll delve into the factors contributing to Wilms tumor.

The Mysterious Origins of Wilms Tumor

The exact cause of Wilms’ tumor remains largely unknown. However, medical researchers have made significant strides in understanding the potential factors that may lead to its development. One of the key factors is genetic mutations.

Genetic Predisposition

Wilms tumor is often associated with certain genetic mutations. In some cases, children with Wilms tumor may have inherited these mutations from their parents. The two most common genetic syndromes associated with Wilms tumor are WAGR syndrome (Wilms tumor, Aniridia, Genitourinary abnormalities, and mental Retardation) and Beckwith-Wiedemann syndrome. These syndromes increase the likelihood of developing Wilms tumor, but they are not the sole cause.

Random Mutations

While genetic factors play a role in some cases, Wilms tumor can also develop spontaneously due to random genetic mutations. These mutations can occur during the early stages of fetal development, leading to the formation of a tumor in the kidney.

Environmental Factors

Unlike some adult cancers, Wilms tumor is not strongly linked to environmental factors such as smoking or exposure to carcinogens. However, ongoing research aims to explore potential environmental triggers or influences that may contribute to its development.

Diagnosis and Treatment of Wilms Tumor

Early detection and diagnosis of Wilms tumor are crucial for successful treatment. Common symptoms include abdominal swelling or pain, blood in the urine, fever, and high blood pressure. Pediatricians often use imaging tests, such as ultrasound and CT scans, to confirm the presence of a tumor.

Once diagnosed, treatment typically involves a combination of surgery, chemotherapy, and radiation therapy. Surgery is the primary approach to remove the tumor while preserving as much healthy kidney tissue as possible. Chemotherapy and radiation therapy are used to target any remaining cancer cells.


In the journey to combat Wilms tumor, parents and caregivers play a vital role. It’s essential to consult with healthcare professionals who specialize in pediatric oncology and surgery to ensure the best possible outcome for your child.

One such expert in the field of pediatric surgery is Dr. Vishesh Dikshit, a renowned pediatric surgeon based in Pune. With a commitment to providing top-notch care and staying updated with the latest advancements in pediatric oncology, Dr. Vishesh Dikshit is dedicated to helping children overcome health challenges, including Wilms tumor.

If you suspect your child may have a Wilms tumor or require guidance on their treatment journey, don’t hesitate to reach out to Dr. Vishesh Dikshit, a trusted name in pediatric surgery in Pune. Your child’s health and well-being are in capable hands.